Visualising Errors in Animal Pedigree Genotype Data

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dc.contributor.authorGraham, Martinen_US
dc.contributor.authorKennedy, Jessieen_US
dc.contributor.authorPaterson, Trevoren_US
dc.contributor.authorLaw, Andyen_US
dc.contributor.editorH. Hauser, H. Pfister, and J. J. van Wijken_US
dc.date.accessioned2014-02-21T20:23:43Z
dc.date.available2014-02-21T20:23:43Z
dc.date.issued2011en_US
dc.description.abstractGenetic analysis of a breeding animal population involves determining the inheritance pattern of genotypes for multiple genetic markers across the individuals in the population pedigree structure. However, experimental pedigree genotype data invariably contains errors in both the pedigree structure and in the associated individual genotypes, introducing inconsistencies into the dataset, rendering them useless for further analysis. The resolution of these errors requires consideration of genotype inheritance patterns in the context of the pedigree structure. Existing pedigree visualisations are typically more suited to human pedigrees and are less suitable for large complex animal pedigrees which may exhibit cross generational inbreeding. Similarly, table-based viewers of genotype marker data can highlight where errors become apparent but lack the functionality and interactive visual feedback to allow users to locate the origin of errors within the pedigree. In this paper, we detail a design study steered by biologists who work with pedigree data, and describe successive iterations through approaches and prototypes for viewing genotyping errors in the context of a displayed pedigree. We describe how each approach performs with real pedigree genotype data and why even-tually we deemed them unsuitable. Finally, a novel prototype visualisation for pedigrees, which we term the 'sandwich view', is detailed and we demonstrate how the approach effectively communicates errors in the pedigree context, supporting the biologist in the error identification task.en_US
dc.description.number3en_US
dc.description.seriesinformationComputer Graphics Forumen_US
dc.description.volume30en_US
dc.identifier.doi10.1111/j.1467-8659.2011.01950.xen_US
dc.identifier.issn1467-8659en_US
dc.identifier.urihttps://doi.org/10.1111/j.1467-8659.2011.01950.xen_US
dc.publisherThe Eurographics Association and Blackwell Publishing Ltd.en_US
dc.subjectH.5.2 [Information Interfaces and Presentation]en_US
dc.subjectUser Interfaces graphical user interfacesen_US
dc.subjectJ.3 [Life and Medical Sciences]en_US
dc.subjectBiology and Genetics.en_US
dc.titleVisualising Errors in Animal Pedigree Genotype Dataen_US
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