Visualization and Exploration of 3D Toponome Data

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dc.contributor.authorOeltze, Steffenen_US
dc.contributor.authorKlemm, Paulen_US
dc.contributor.authorHillert, Reyken_US
dc.contributor.authorPreim, Bernharden_US
dc.contributor.authorSchubert, Walteren_US
dc.contributor.editorTimo Ropinski and Anders Ynnerman and Charl Botha and Jos Roerdinken_US
dc.date.accessioned2013-11-08T10:34:21Z
dc.date.available2013-11-08T10:34:21Z
dc.date.issued2012en_US
dc.description.abstractThe toponome of a cell describes the location and topological distribution of proteins across the cell. In toponomics, the toponome is imaged and its inner structure and its semantics are investigated in order to understand how cells encode different functionalities both in health and disease. Toponome imaging results in complex multiparameter data composed of a 3D volume per protein affinity reagent. After imaging, the data is binarized such that 1 encodes protein present and 0 encodes protein absent. Biologists are particularly interested in the clustering of these binary protein patterns and in the distribution of clusters across the cell. We present a volume rendering approach for visualizing all unique protein patterns in 3D. A unique color is dynamically assigned to each pattern such that a sufficient perceptual difference between colors in the current view is guaranteed. We further present techniques for interacting with the view in an exploratory analysis. The biologist may for instance ''peel of'' clusters thereby revealing occluded cell structures. The 3D view is integrated in a multiple coordinated view system. Peeling off clusters or brushing protein patterns in the view updates all other views. We demonstrate the utility of the view with a cell sample containing lymphocytes.en_US
dc.description.seriesinformationEurographics Workshop on Visual Computing for Biology and Medicineen_US
dc.identifier.isbn978-3-905674-38-5en_US
dc.identifier.issn2070-5778en_US
dc.identifier.urihttps://doi.org/10.2312/VCBM/VCBM12/115-122en_US
dc.publisherThe Eurographics Associationen_US
dc.subjectJ.3 [Computer Applications]en_US
dc.subjectLife and Medical Sciencesen_US
dc.subjectBiology and geneticsen_US
dc.titleVisualization and Exploration of 3D Toponome Dataen_US
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VCBM 12: Eurographics Workshop on Visual Computing for Biology and Medicine