An Experimental Shape Matching Approach for Protein Docking
| dc.contributor.author | Fernandes, Francisco | en_US |
| dc.contributor.author | Ferreira, Alfredo | en_US |
| dc.contributor.editor | A. Ferreira and A. Giachetti and D. Giorgi | en_US |
| dc.date.accessioned | 2016-05-04T16:04:58Z | |
| dc.date.available | 2016-05-04T16:04:58Z | |
| dc.date.issued | 2016 | en_US |
| dc.description.abstract | Proteins play a vital role in biological processes, with their function being largely determined by their structure. It is important to know what a protein binds, where it binds, how it binds, and what is its final conformation. Several methodologies have been applied to solve this complex protein-protein docking problem, but the number of degrees of freedom renders this a very slow and computationally heavy challenge. To handle this problem, we propose a multi-level space partition approach to describe the three-dimensional shape of the protein. By combining two proteins in the same data structure we are able to easily detect the shape-complementary regions. Moreover, by directly integrating bio-energetic information, we can drive the algorithm by both parameters and provide a fast and efficient way to overcome some of the limitations of previous approaches. | en_US |
| dc.description.sectionheaders | Full Papers | en_US |
| dc.description.seriesinformation | Eurographics Workshop on 3D Object Retrieval | en_US |
| dc.identifier.doi | 10.2312/3dor.20161083 | en_US |
| dc.identifier.isbn | 978-3-03868-004-8 | en_US |
| dc.identifier.issn | 1997-0471 | en_US |
| dc.identifier.pages | 21-25 | en_US |
| dc.identifier.uri | https://doi.org/10.2312/3dor.20161083 | en_US |
| dc.publisher | The Eurographics Association | en_US |
| dc.subject | I.3.5 [Computer Graphics] | en_US |
| dc.subject | Computational Geometry and Object Modeling | en_US |
| dc.subject | Curve | en_US |
| dc.subject | surface | en_US |
| dc.subject | solid | en_US |
| dc.subject | and object representations | en_US |
| dc.title | An Experimental Shape Matching Approach for Protein Docking | en_US |
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