Annotated Dendrograms for Neurons From the Larval Fruit Fly Brain

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dc.contributor.authorStrauch, Martinen_US
dc.contributor.authorHartenstein, Volkeren_US
dc.contributor.authorAndrade, Ingrid V.en_US
dc.contributor.authorCardona, Alberten_US
dc.contributor.authorMerhof, Doriten_US
dc.contributor.editorPuig Puig, Anna and Schultz, Thomas and Vilanova, Anna and Hotz, Ingrid and Kozlikova, Barbora and Vázquez, Pere-Pauen_US
dc.date.accessioned2018-09-19T15:19:22Z
dc.date.available2018-09-19T15:19:22Z
dc.date.issued2018
dc.description.abstractRecent advances in neuroscience have made it possible to reconstruct all neurons of an entire neural circuit in the larval fruit fly brain from serial electron microscopy image stacks. The reconstructed neurons are morphologically complex 3D graphs whose nodes are annotated with labels representing different types of synapses. Here, we propose a method to draw simplified, yet realistic 2D neuron sketches of insect neurons in order to help biologists formulate hypotheses on neural function at the microcircuit level. The sketches are dendrograms that capture a neuron's branching structure and that preserve branch lengths, providing realistic estimates for distances and signal travel times between synapses. To improve readability of the often densely clustered synapse annotations, synapses are automatically summarized in local clusters of synapses of the same type and arranged to minimize label overlap. We show that two major neuron classes of an olfactory circuit in the larval fruit fly brain can be discriminated visually based on the dendrograms. Unsupervised and supervised data analysis reveals that class discrimination can be performed using morphological features derived from the dendrograms.en_US
dc.description.sectionheadersHead and Brain
dc.description.seriesinformationEurographics Workshop on Visual Computing for Biology and Medicine
dc.identifier.doi10.2312/vcbm.20181229
dc.identifier.isbn978-3-03868-056-7
dc.identifier.issn2070-5786
dc.identifier.pages57-66
dc.identifier.urihttps://diglib.eg.org:443/handle/10.2312/vcbm20181229
dc.identifier.urihttps://doi.org/10.2312/vcbm.20181229
dc.publisherThe Eurographics Associationen_US
dc.subjectHuman
dc.subjectcentered computing
dc.subjectVisualization techniques
dc.subjectScientific visualization
dc.titleAnnotated Dendrograms for Neurons From the Larval Fruit Fly Brainen_US
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VCBM 18: Eurographics Workshop on Visual Computing for Biology and Medicine