VCBM 17: Eurographics Workshop on Visual Computing for Biology and Medicine

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https://diglib.eg.org/handle/10.2312/2631687

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Browsing VCBM 17: Eurographics Workshop on Visual Computing for Biology and Medicine by Subject "I.3.3 [Computer Graphics]"

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    Concentric Circle Glyphs for Enhanced Depth-Judgment in Vascular Models
    (The Eurographics Association, 2017) Lichtenberg, Nils; Hansen, Christian; Lawonn, Kai; Stefan Bruckner and Anja Hennemuth and Bernhard Kainz and Ingrid Hotz and Dorit Merhof and Christian Rieder
    Using 3D models of medical data for surgery or treatment planning requires a comprehensive visualization of the data. This is crucial to support the physician in creating a cognitive image of the presented model. Vascular models are complex structures and, thus, the correct spatial interpretation is difficult. We propose view-dependent circle glyphs that enhance depth perception in vascular models. The glyphs are automatically placed on vessel end-points in a balanced manner. For this, we introduce a vessel end-point detection algorithm as a pre-processing step and an extensible, feature-driven glyph filtering strategy. Our glyphs are simple to implement and allow an enhanced and quick judgment of the depth value that they represent. We conduct a qualitative evaluation to compare our approach with two existing approaches, that enhance depth perception with illustrative visualization techniques. The evaluation shows that our glyphs perform better in the general case and decisively outperform the reference techniques when it comes to just noticeable differences.
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    Protein Tunnel Reprojection for Physico-Chemical Property Analysis
    (The Eurographics Association, 2017) Malzahn, Jan; Kozlíková, Barbora; Ropinski, Timo; Stefan Bruckner and Anja Hennemuth and Bernhard Kainz and Ingrid Hotz and Dorit Merhof and Christian Rieder
    Cavities are crucial for interactions of proteins with other molecules. While a variety of different cavity types exists, tunnels in particular play an important role, as they enable a ligand to deeply enter the active site of a protein where chemical reactions can undergo. Consequently, domain scientists are interested in understanding properties relevant for binding interactions inside molecular tunnels. Unfortunately, when inspecting a 3D representation of the molecule under investigation, tunnels are difficult to analyze due to occlusion issues. Therefore, within this paper we propose a novel reprojection technique that transforms the 3D structure of a molecule to obtain a 2D representation of the tunnel interior. The reprojection has been designed with respect to application-oriented design guidelines, we have identified together with our domain partners. To comply with these guidelines, the transformation preserves individual residues, while the result is capable of showing binding properties inside the tunnel without suffering from occlusions. Thus the reprojected tunnel interior can be used to display physico-chemical properties, e.g., hydrophobicity or amino acid orientation, of residues near a tunnel's surface. As these properties are essential for the interaction between protein and ligand, they can thus hint angles of attack for protein engineers. To demonstrate the benefits of the developed visualization, the obtained results are discussed with respect to domain expert feedback.