Knowledge-Assisted Comparative Assessment of Breast Cancer using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

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dc.contributor.authorNie, Kaien_US
dc.contributor.authorBaltzer, Pascalen_US
dc.contributor.authorPreim, Bernharden_US
dc.contributor.authorMistelbauer, Gabrielen_US
dc.contributor.editorViola, Ivan and Gleicher, Michael and Landesberger von Antburg, Tatianaen_US
dc.date.accessioned2020-05-24T12:59:57Z
dc.date.available2020-05-24T12:59:57Z
dc.date.issued2020
dc.description.abstractBreast perfusion data are dynamic medical image data that depict perfusion characteristics of the investigated tissue. These data consist of a series of static datasets that are acquired at different time points and aggregated into time intensity curves (TICs) for each voxel. The characteristics of these TICs provide important information about a lesion's composition, but their analysis is time-consuming due to their large number. Subsequently, these TICs are used to classify a lesion as benign or malignant. This lesion scoring is commonly done manually by physicians and may therefore be subject to bias. We propose an approach that addresses both of these problems by combining an automated lesion classification with a visual confirmatory analysis, especially for uncertain cases. Firstly, we cluster the TICs of a lesion using ordering points to identify the clustering structure (OPTICS) and then visualize these clusters. Together with their relative size, they are added to a library. We then model fuzzy inference rules by using the lesion's TIC clusters as antecedents and its score as consequent. Using a fuzzy scoring system, we can suggest a score for a new lesion. Secondly, to allow physicians to confirm the suggestion in uncertain cases, we display the TIC clusters together with their spatial distribution and allow them to compare two lesions side by side. With our knowledge-assisted comparative visual analysis, physicians can explore and classify breast lesions. The true positive prediction accuracy of our scoring system achieved 71.4% in one-fold cross-validation using 14 lesions.en_US
dc.description.number3
dc.description.sectionheadersVolumes
dc.description.seriesinformationComputer Graphics Forum
dc.description.volume39
dc.identifier.doi10.1111/cgf.13959
dc.identifier.issn1467-8659
dc.identifier.pages13-23
dc.identifier.urihttps://doi.org/10.1111/cgf.13959
dc.identifier.urihttps://diglib.eg.org:443/handle/10.1111/cgf13959
dc.publisherThe Eurographics Association and John Wiley & Sons Ltd.en_US
dc.rightsAttribution 4.0 International License
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/]
dc.subjectHuman centered computing
dc.subjectGraph drawings
dc.subjectVisual analytics
dc.subjectInformation visualization
dc.subjectComputing methodologies
dc.subjectVagueness and fuzzy logic
dc.subjectInformation systems
dc.subjectClustering
dc.subjectDigital libraries and archives
dc.titleKnowledge-Assisted Comparative Assessment of Breast Cancer using Dynamic Contrast-Enhanced Magnetic Resonance Imagingen_US
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