Mesoscope: A Web-based Tool for Mesoscale Data Integration and Curation
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
The Eurographics Association
Abstract
Interest is growing for 3D models of the biological mesoscale, the intermediate scale between the nanometer scale of molecular structure and micrometer scale of cellular biology. However, it is currently difficult to gather, curate and integrate all the data required to define such models. To address this challenge we developed Mesoscope (mesoscope.scripps.edu/beta), a web-based data integration and curation tool. Mesoscope allows users to begin with a listing of molecules (such as data from proteomics), and to use resources at UniProt and the PDB to identify, prepare and validate appropriate structures and representations for each molecule, ultimately producing a portable output file used by CellPACK and other modeling tools for generation of 3D models of the biological mesoscale. The availability of this tool has proven essential in several exploratory applications, given the high complexity of mesoscale models and the heterogeneity of the available data sources.
Description
@inproceedings{10.2312:molva.20201098,
booktitle = {Workshop on Molecular Graphics and Visual Analysis of Molecular Data},
editor = {Byška, Jan and Krone, Michael and Sommer, Björn},
title = {{Mesoscope: A Web-based Tool for Mesoscale Data Integration and Curation}},
author = {Autin, Ludovic and Maritan, Martina and Barbaro, Brett A. and Gardner, Adam and Olson, Arthur J. and Sanner, Michel and Goodsell, David S.},
year = {2020},
publisher = {The Eurographics Association},
ISBN = {978-3-03868-114-4},
DOI = {10.2312/molva.20201098}
}