Mesoscope: A Web-based Tool for Mesoscale Data Integration and Curation

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dc.contributor.authorAutin, Ludovicen_US
dc.contributor.authorMaritan, Martinaen_US
dc.contributor.authorBarbaro, Brett A.en_US
dc.contributor.authorGardner, Adamen_US
dc.contributor.authorOlson, Arthur J.en_US
dc.contributor.authorSanner, Michelen_US
dc.contributor.authorGoodsell, David S.en_US
dc.contributor.editorByška, Jan and Krone, Michael and Sommer, Björnen_US
dc.date.accessioned2020-05-24T13:29:47Z
dc.date.available2020-05-24T13:29:47Z
dc.date.issued2020
dc.description.abstractInterest is growing for 3D models of the biological mesoscale, the intermediate scale between the nanometer scale of molecular structure and micrometer scale of cellular biology. However, it is currently difficult to gather, curate and integrate all the data required to define such models. To address this challenge we developed Mesoscope (mesoscope.scripps.edu/beta), a web-based data integration and curation tool. Mesoscope allows users to begin with a listing of molecules (such as data from proteomics), and to use resources at UniProt and the PDB to identify, prepare and validate appropriate structures and representations for each molecule, ultimately producing a portable output file used by CellPACK and other modeling tools for generation of 3D models of the biological mesoscale. The availability of this tool has proven essential in several exploratory applications, given the high complexity of mesoscale models and the heterogeneity of the available data sources.en_US
dc.description.sectionheadersSession 2
dc.description.seriesinformationWorkshop on Molecular Graphics and Visual Analysis of Molecular Data
dc.identifier.doi10.2312/molva.20201098
dc.identifier.isbn978-3-03868-114-4
dc.identifier.pages23-31
dc.identifier.urihttps://doi.org/10.2312/molva.20201098
dc.identifier.urihttps://diglib.eg.org:443/handle/10.2312/molva20201098
dc.publisherThe Eurographics Associationen_US
dc.rightsAttribution 4.0 International License
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/]
dc.subjectApplied computing
dc.subjectBioinformatics
dc.subjectComputing methodologies
dc.subjectGraphics systems and interfaces
dc.titleMesoscope: A Web-based Tool for Mesoscale Data Integration and Curationen_US
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MolVa: Workshop on Molecular Graphics and Visual Analysis of Molecular Data 2020